When fibrinolytic therapy is administered to patients with ST segment depression only, we kill an additional 14 patients per 1000 treated.
When fibrinolytic therapy is administered to patients with a “normal” admission 12 lead ECG, we kill an additional 7 patients per 1000 treated.
The Fibrinolytic Therapy Trialists (FTT) Collaborative Group obtained patient data from over 60,000 patients in 22 trials. Of those, 4% had BBB, 68% had ST segment elevation, 7% had ST segment depression, 17% had other abnormalities (e.g., inverted T waves), and 5% had near-normal ECGs.
Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients. Lancet 1994; 343: 311-22